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SHAREHOLDER LETTER

Lackluster first quarter for biotech stocks

Concerns about capital market resilience clearly had an impact on investor preferences during the first quarter. After a strong start to the year, market sentiment switched to risk-off and this triggered heavy selling in the small- and mid-cap segments. Portfolio investment flows in the biotech sector – an important indicator – remained negative. Smaller biotech companies underperformed relative to their larger peers. In contrast to the sector performance, many biotech companies reported positive R&D and regulatory news.

Performance

BB BIOTECH (SIX)

CHF 49.95

31.03.2023

Share Price Performance YTD

-4.4%

Market capitalisation

CHF 2.8 bn

Net Asset Value (NAV)

CHF 41.50

BB BIOTECH (XETRA)

EUR 50.00

31.03.2023

Share Price Performance YTD

-6.8%

Market capitalisation

EUR 2.8 bn

Net Asset Value (NAV)

EUR 41.85

BB BIOTECH (STAR)

EUR 50.30

31.03.2023

Share Price Performance YTD

-6.0%

Market capitalisation

EUR 2.8 bn

Net Asset Value (NAV)

EUR 41.85

Portfolio

Ionis Pharmaceuticals

11.9%

31.03.2023

Argenx SE

11.5%

31.03.2023

Vertex Pharmaceuticals

10.0%

31.03.2023

Neurocrine Biosciences

9.3%

31.03.2023

Moderna

8.0%

31.03.2023

Incyte

7.1%

31.03.2023

Intra-Cellular Therapeutics

6.1%

31.03.2023

Alnylam Pharmaceuticals

6.0%

31.03.2023

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