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4. Financial assets

Fair values

The following table presents the Group’s assets that are measured at fair value through profit and loss at December 31 (in CHF 1 000):

2024

Level 1

Level 2

Level 3

Total

Assets

Securities

- Shares

2 369 436

37 444

2 406 881

- Derivative instruments

Total assets

2 369 436

37 444

2 406 881

2023

Assets

Securities

- Shares

2 619 989

14 725

2 634 714

- Derivative instruments

Total assets

2 619 989

14 725

2 634 714

There were no transfers between level 1, 2 and 3 during the reporting period.

The fair value of financial instruments traded in active markets is based on quoted market prices at the balance sheet date. A market is regarded as active if quoted prices are readily and regularly available and those prices represent actual and regularly occurring market transactions on an arm’s length basis. The quoted market price used for financial assets held by the Group is the closing price. These instruments are included in level 1.

The fair value of financial instruments that are not traded in an active market is determined by using valuation techniques. These valuation techniques maximize the use of observable market data where it is available. The options are valued on the basis of the Black-Scholes model which is based on market conditions existing at each balance sheet date. These instruments are included in level 2.

If one or more of the significant inputs is not based on observable market data, the instrument is included in level 3. The valuation of level 3 instruments is quarterly reviewed. As soon as new or adjusted parameters are available the valuation of unlisted shares is adjusted accordingly (e.g. earnings multiple model, round of financing). As of December 31, 2024, the Company holds two level 3 instruments (December 31, 2023: two), whereas the value of one is zero.

The table below summarizes the transactions in level 3 instruments (in CHF 1 000):

2024

2023

Opening balance

14 725

16 179

Purchases

15 139

Unrealized gains/(losses) included in gains/losses from securities

7 581

(1 454)

Closing balance

37 444

14 725

Gains/(losses) on level 3 instruments included in gains/losses from securities

7 581

(1 454)

The fair value of level 3 instruments at initial recognition represents the transaction price (purchase of preferred stocks of Rivus Pharmaceuticals in August 2022 for TCHF 16 875 and August 2024 for TCHF 15 139), which was paid in financing rounds together with other investors. For the valuation as at December 31, 2024, it is deemed to be appropriate to use the latest transaction price in USD, as it is a reasonable approximation of fair value at the valuation date given the fact that no events occurred which significantly impact the fair value.

In August 2022, 8 733 538 Radius Health – Contingent Value Rights were allocated from a corporate action. The valuation as of December 31, 2024, is CHF 0 (December 31, 2023: CHF 0).

For assets and liabilities carried at amortized cost, their carrying values are a reasonable approximation of fair value.

Key assumptions for the valuation of the level 3 financial instrument vary from investment to investment. The following table shows the effect on the valuation when these assumptions are changed:

Sensitivity analysis

Fair value

Key assumption

Changes in key assumption

Change in fair value in CHF 1 000

Unlisted shares

37 444

Transaction price

+ 5 percentage points

+ 1872

- 5 percentage points

- 1872

Contingent Value Rights

0

Net sales target of a drug

Not met

0

Met

+ 7925

Securities

The changes in value of securities by investment category are as follows (in CHF 1 000):

Listed shares

Unlisted shares

Derivative instruments

Total

Opening balance as at 01.01.2023 at fair values

3 035 170

16 179

3 051 349

Purchases

201 147

201 147

Sales

(451 169)

(451 169)

Gains/(losses) from securities

(165 158)

(1 454)

(166 613)

Realized gains

28 749

28 749

Realized losses

(46 543)

(46 543)

Unrealized gains

276 764

276 764

Unrealized losses

(424 128)

(1 454)

(425 582)

Closing balance as at 31.12.2023 at fair values

2 619 989

14 725

2 634 714

Opening balance as at 01.01.2024 at fair values

2 619 989

14 725

2 634 714

Purchases

206 303

15 139

316

221 758

Sales

(561 097)

(42)

(561 139)

Gains/(losses) from securities

104 241

7 581

(274)

111 548

Realized gains

107 900

107 900

Realized losses

(46 182)

(274)

(46 456)

Unrealized gains

480 172

7 581

487 753

Unrealized losses

(437 649)

(437 649)

Closing balance as at 31.12.2024 at fair values

2 369 436

37 444

2 406 881

Securities comprise the following:

Company

Number 31.12.2023

Change

Number 31.12.2024

Market price in original currency 31.12.2024

Valuation CHF mn 31.12.2024

Valuation CHF mn 31.12.2023

Argenx SE

825 000

(234 000)

591 000

USD

615.00

329.8

264.1

Ionis Pharmaceuticals

8 590 000

(740 000)

7 850 000

USD

34.96

249.0

365.6

Neurocrine Biosciences

2 410 000

(590 000)

1 820 000

USD

136.50

225.4

267.2

Intra-Cellular Therapies

3 040 000

(615 000)

2 425 000

USD

83.52

183.8

183.2

Revolution Medicines

5 046 700

(672 400)

4 374 300

USD

43.74

173.6

121.8

Vertex Pharmaceuticals

640 000

(165 000)

475 000

USD

402.70

173.6

219.1

Alnylam Pharmaceuticals

859 700

(99 700)

760 000

USD

235.31

162.3

138.5

Incyte

2 150 000

2 150 000

USD

69.07

134.7

113.6

Agios Pharmaceuticals

4 000 000

(484 850)

3 515 150

USD

32.86

104.8

75.0

Scholar Rock Holding

2 132 725

353 982

2 486 707

USD

43.22

97.5

33.7

Celldex Therapeutics

2 416 296

655 319

3 071 615

USD

25.27

70.4

80.6

Biohaven

1 075 000

965 853

2 040 853

USD

37.35

69.2

38.7

Moderna

1 891 075

(291 075)

1 600 000

USD

41.58

60.4

158.2

Wave Life Sciences

4 494 458

(400 000)

4 094 458

USD

12.37

46.0

19.1

Arvinas

2 494 531

(114 531)

2 380 000

USD

19.17

41.4

86.4

Edgewise Therapeutics

1 428 929

1 428 929

USD

26.70

34.6

Beam Therapeutics

693 121

825 000

1 518 121

USD

24.80

34.2

15.9

Immunocore

965 654

239 810

1 205 464

USD

29.50

32.3

55.5

Macrogenics

9 929 963

9 929 963

USD

3.25

29.3

80.4

Relay Therapeutics

5 925 000

1 450 000

7 375 000

USD

4.12

27.6

54.9

Annexon

5 157 290

5 157 290

USD

5.13

24.0

Sage Therapeutics

3 505 000

955 693

4 460 693

USD

5.43

22.0

63.9

Esperion Therapeutics

4 194 064

5 750 000

9 944 064

USD

2.20

19.9

10.6

Black Diamond Therapeutics

8 517 839

8 517 839

USD

2.14

16.5

20.1

Fate Therapeutics

4 839 779

4 839 779

USD

1.65

7.2

15.2

Crispr Therapeutics

880 000

(880 000)

USD

n.a.

46.4

Essa Pharma

7 879 583

(7 879 583)

USD

n.a.

43.8

Exelixis

2 000 000

(2 000 000)

USD

n.a.

40.4

Generation Bio Co.

3 608 280

(3 608 280)

USD

n.a.

5.0

Molecular Templates

1 029 820

(1 029 820)

USD

n.a.

3.2

Listed shares

2 369.5

2 620.0

Rivus Pharmaceuticals

USD

37.4

14.7

Unlisted shares

37.4

14.7

Total shares

2 406.9

2 634.7

Molecular Templates – Warrants, 2.4.29

769 334

769 334

USD

0.00

0.0

Radius Health – Contingent Value Right

8 733 538

8 733 538

USD

0.00

0.0

Total derivative instruments

Total securities

2 406.9

2 634.7

Securities are deposited with Bank Julius Baer & Co. Ltd., Zurich.