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one of the leading biotech investors

SHAREHOLDER LETTER

Sharpened portfolio focus amid continued market volatility

Q1 2025 was characterized by elevated volatility across global financial markets, driven by increasing political uncertainty and evolving trade policies. Tariffs reintroduced by the Trump administration weighed on US consumer sentiment and contributed to a rise in inflation expectations, prompting growing concerns about a potential stagflationary environment. Against this turbulent macroeconomic backdrop, the biotech sector faced a particularly challenging quarter. Healthcare policy uncertainties, coupled with sustained market volatility, continued to weigh heavily on the industry, testing the resilience of both companies and investors alike.

Performance

BB BIOTECH (SIX)

CHF 30.55

31.03.2025

Share Price Performance YTD

-13.7%

Market capitalisation

CHF 1.7 bn

Net Asset Value (NAV)

CHF 35.55

BB BIOTECH (XETRA)

EUR 31.80

31.03.2025

Share Price Performance YTD

-15.1%

Market capitalisation

EUR 1.8 bn

Net Asset Value (NAV)

EUR 37.15

Portfolio

Argenx SE

16.2%

31.03.2025

Ionis Pharmaceuticals

11.3%

31.03.2025

Alnylam Pharmaceuticals

9.8%

31.03.2025

Neurocrine Biosciences

9.6%

31.03.2025

Vertex Pharmaceuticals

9.2%

31.03.2025

Revolution Medicines

7.4%

31.03.2025

Incyte

6.0%

31.03.2025

Agios Pharmaceuticals

4.9%

31.03.2025

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