4. Financial assets
Securities
Securities comprise the following:
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Company |
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Number 31.12.2020 |
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Change |
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Number 30.09.2021 |
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Market price in original currency 30.09.2021 |
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Valuation CHF mn 30.09.2021 |
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Valuation CHF mn 31.12.2020 |
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Moderna |
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2 854 963 |
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(1 176 614) |
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1 678 349 |
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USD |
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384.86 |
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601.8 |
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264.0 |
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Ionis Pharmaceuticals |
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8 220 000 |
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892 973 |
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9 112 973 |
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USD |
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33.54 |
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284.8 |
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411.4 |
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Argenx SE |
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921 332 |
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34 206 |
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955 538 |
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USD |
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302.00 |
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268.9 |
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239.8 |
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Neurocrine Biosciences |
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3 035 000 |
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(119 600) |
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2 915 400 |
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USD |
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95.91 |
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260.5 |
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257.5 |
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Alnylam Pharmaceuticals |
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1 155 000 |
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(45 000) |
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1 110 000 |
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USD |
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188.81 |
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195.3 |
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132.9 |
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Incyte |
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2 900 000 |
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(3 000) |
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2 897 000 |
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USD |
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68.78 |
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185.6 |
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223.3 |
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Agios Pharmaceuticals |
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4 158 902 |
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146 090 |
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4 304 992 |
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USD |
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46.15 |
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185.1 |
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159.5 |
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Vertex Pharmaceuticals |
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900 000 |
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150 000 |
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1 050 000 |
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USD |
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181.39 |
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177.5 |
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188.3 |
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Fate Therapeutics |
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2 030 000 |
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1 156 336 |
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3 186 336 |
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USD |
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59.27 |
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176.0 |
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163.4 |
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Arvinas |
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2 176 903 |
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– |
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2 176 903 |
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USD |
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82.18 |
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166.7 |
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163.7 |
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Macrogenics |
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4 815 564 |
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2 260 000 |
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7 075 564 |
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USD |
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20.94 |
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138.0 |
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97.4 |
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Biogen |
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537 000 |
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(37 000) |
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500 000 |
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USD |
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282.99 |
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131.8 |
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116.4 |
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Sage Therapeutics |
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1 540 104 |
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1 630 000 |
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3 170 104 |
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USD |
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44.31 |
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130.9 |
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117.9 |
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Intra-Cellular Therapies |
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3 538 419 |
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125 000 |
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3 663 419 |
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USD |
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37.28 |
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127.2 |
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99.6 |
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Myovant Sciences |
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4 757 039 |
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965 000 |
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5 722 039 |
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USD |
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22.44 |
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119.6 |
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116.3 |
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Relay Therapeutics |
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1 409 357 |
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2 326 605 |
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3 735 962 |
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USD |
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31.53 |
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109.7 |
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51.8 |
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Crispr Therapeutics |
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900 884 |
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48 700 |
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949 584 |
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USD |
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111.93 |
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99.0 |
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122.1 |
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Radius Health |
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7 455 714 |
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250 000 |
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7 705 714 |
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USD |
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12.41 |
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89.1 |
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117.9 |
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Revolution Medicines |
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– |
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3 410 105 |
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3 410 105 |
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USD |
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27.51 |
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87.4 |
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– |
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Scholar Rock Holding |
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2 255 651 |
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19 474 |
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2 275 125 |
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USD |
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33.02 |
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70.0 |
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96.9 |
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Molecular Templates |
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6 380 331 |
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4 411 672 |
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10 792 003 |
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USD |
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6.71 |
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67.5 |
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53.0 |
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Generation Bio Co. |
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2 333 180 |
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120 000 |
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2 453 180 |
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USD |
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25.07 |
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57.3 |
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58.6 |
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Exelixis |
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2 835 000 |
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– |
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2 835 000 |
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USD |
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21.14 |
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55.8 |
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50.4 |
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Esperion Therapeutics |
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3 947 964 |
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530 000 |
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4 477 964 |
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USD |
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12.05 |
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50.3 |
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90.9 |
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Beam Therapeutics |
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396 821 |
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210 000 |
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606 821 |
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USD |
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87.01 |
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49.2 |
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28.7 |
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Nektar Therapeutics |
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2 620 676 |
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– |
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2 620 676 |
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USD |
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17.96 |
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43.9 |
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39.4 |
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Essa Pharma |
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– |
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5 015 814 |
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5 015 814 |
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USD |
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8.00 |
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37.4 |
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– |
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Kezar Life Sciences |
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4 533 148 |
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– |
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4 533 148 |
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USD |
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8.64 |
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36.5 |
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20.9 |
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Mersana Therapeutics |
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1 885 000 |
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2 250 000 |
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4 135 000 |
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USD |
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9.43 |
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36.3 |
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44.4 |
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Black Diamond Therapeutics |
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1 390 000 |
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2 050 000 |
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3 440 000 |
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USD |
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8.46 |
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27.1 |
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39.4 |
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Homology Medicines |
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1 737 122 |
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– |
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1 737 122 |
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USD |
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7.87 |
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12.7 |
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17.4 |
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Wave Life Sciences |
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2 602 858 |
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– |
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2 602 858 |
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USD |
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4.90 |
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11.9 |
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18.1 |
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Alexion Pharmaceuticals |
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1 294 428 |
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(1 294 428) |
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– |
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USD |
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n.a |
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– |
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179.0 |
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Halozyme Therapeutics |
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3 970 000 |
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(3 970 000) |
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– |
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USD |
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n.a |
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– |
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150.1 |
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Voyager Therapeutics |
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2 680 283 |
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(2 680 283) |
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– |
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USD |
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n.a |
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– |
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17.0 |
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Cidara Therapeutics |
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2 822 495 |
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(2 822 495) |
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– |
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USD |
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n.a |
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– |
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5.0 |
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Total shares |
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4 090.8 |
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3 952.5 |
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Alder Biopharmaceuticals – Contingent Value Right |
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2 766 008 |
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– |
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2 766 008 |
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USD |
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0.88 |
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2.3 |
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2.2 |
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Bristol-Myers Squibb – Contingent Value Right |
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800 000 |
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(800 000) |
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– |
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USD |
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n.a |
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– |
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– |
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Total derivative instruments |
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2.3 |
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2.2 |
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Total securities |
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4 093.1 |
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3 954.7 |
The changes in value of securities at fair value through profit or loss by investment category are as follows (in CHF 1 000):
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Listed shares |
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Unlisted shares |
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Derivative instruments |
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Total |
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Opening balance as at 01.01.2020 at fair values |
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3 518 985 |
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– |
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4 685 |
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3 523 670 |
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Purchases |
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699 570 |
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– |
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– |
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699 570 |
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Sales |
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(1 010 092) |
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– |
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– |
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(1 010 092) |
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Net gains/(losses) from securities |
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744 042 |
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– |
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(2 531) |
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741 511 |
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Realized gains |
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364 618 |
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– |
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– |
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364 618 |
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Realized losses |
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(83 963) |
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– |
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– |
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(83 963) |
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Unrealized gains |
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882 536 |
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– |
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– |
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882 536 |
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Unrealized losses |
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(419 149) |
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– |
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(2 531) |
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(421 680) |
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Closing balance as at 31.12.2020 at fair values |
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3 952 504 |
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– |
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2 155 |
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3 954 659 |
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Opening balance as at 01.01.2021 at fair values |
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3 952 504 |
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– |
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2 155 |
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3 954 659 |
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Purchases |
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796 287 |
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– |
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– |
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796 287 |
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Sales |
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(845 013) |
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– |
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– |
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(845 013) |
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Net gains/(losses) from securities |
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187 057 |
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– |
|
113 |
|
187 170 |
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Realized gains |
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271 885 |
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– |
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– |
|
271 885 |
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Realized losses |
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(1 530) |
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– |
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(2 330) |
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(3 860) |
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Unrealized gains |
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649 723 |
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– |
|
113 |
|
649 836 |
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Unrealized losses |
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(733 022) |
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– |
|
2 330 |
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(730 692) |
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Closing balance as at 30.09.2021 at fair values |
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4 090 835 |
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– |
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2 268 |
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4 093 103 |