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4. Financial assets

Fair values

The following table presents the Group’s assets that are measured at fair value through profit and loss at December 31 (in CHF 1 000):

2023

Level 1

Level 2

Level 3

Total

Assets

Securities

- Shares

2 619 989

14 725

2 634 714

- Derivative instruments

Total assets

2 619 989

14 725

2 634 714

2022

Assets

Securities

- Shares

3 035 170

16 179

3 051 349

- Derivative instruments

Total assets

3 035 170

16 179

3 051 349

The fair value of financial instruments traded in active markets is based on quoted market prices at the balance sheet date. A market is regarded as active if quoted prices are readily and regularly available and those prices represent actual and regularly occurring market transactions on an arm’s length basis. The quoted market price used for financial assets held by the Group is the closing price. These instruments are included in level 1.

The fair value of financial instruments that are not traded in an active market is determined by using valuation techniques. These valuation techniques maximize the use of observable market data where it is available. The options are valued on the basis of the Black-Scholes model which is based on market conditions existing at each balance sheet date. These instruments are included in level 2.

If one or more of the significant inputs is not based on observable market data, the instrument is included in level 3. The valuation of level 3 instruments is quarterly reviewed. As soon as new or adjusted parameters are available the valuation model (e.g. earnings multiple model) of unlisted shares is adjusted accordingly. As of December 31, 2023, the Company holds one level 3 instrument (December 31, 2022: one).

The table below summarizes the transactions in level 3 instruments (in CHF 1 000):

2023

2022

Opening balance

16 179

2 222

Purchases

16 875

Sales

(5 071)

Realized gains/(losses) included in gains/losses from securities

2 849

Unrealized gains/(losses) included in gains/losses from securities

(1 454)

(697)

Closing balance

14 725

16 179

Gains/(losses) on level 3 instruments included in gains/losses from securities

(1 454)

2 152

There were no transfers between level 1, 2 and 3 during the reporting period. No sensitivity analysis has been disclosed due to the immaterial amount of level 3 instruments.

The level 3 instrument as at December 31, 2021, (Valuation: TCHF 2 222) was allocated as part of a corporate action in 2019 and sold at a value of TCHF 5 071 in March 2022.

The fair value of the level 3 instrument at initial recognition represents the transaction price (purchase of Series B-1 Preferred Stock of Rivus Pharmaceuticals in August 2022 for TCHF 16 875), which was paid in a financing round together with other investors. For the valuation as at December 31, 2023, it is deemed to be appropriate to use the transaction price in USD, as it is a reasonable approximation of fair value at the valuation date given the fact that no events occurred which significantly impact the fair value.

In August 2022, 8 733 538 Radius Health – Contingent Value Rights were allocated from a corporate action. The valuation as of December 31, 2023, is CHF 0 (December 31, 2022: CHF 0).

For assets and liabilities carried at amortized cost, their carrying values are a reasonable approximation of fair value.

Securities

The changes in value of securities by investment category are as follows (in CHF 1 000):

Listed shares

Unlisted shares

Derivative instruments

Total

Opening balance as at 01.01.2022 at fair values

3 638 890

2 222

3 641 112

Purchases

183 812

16 875

200 687

Sales

(471 115)

(5 071)

(476 186)

Gains/(losses) from securities

(316 417)

(697)

2 849

(314 265)

Realized gains

47 563

2 849

50 412

Realized losses

(79 326)

(79 326)

Unrealized gains

437 200

437 200

Unrealized losses

(721 854)

(697)

(722 551)

Closing balance as at 31.12.2022 at fair values

3 035 170

16 179

3 051 349

Opening balance as at 01.01.2023 at fair values

3 035 170

16 179

3 051 349

Purchases

201 147

201 147

Sales

(451 169)

(451 169)

Gains/(losses) from securities

(165 158)

(1 454)

(166 613)

Realized gains

28 749

28 749

Realized losses

(46 543)

(46 543)

Unrealized gains

276 764

276 764

Unrealized losses

(424 128)

(1 454)

(425 582)

Closing balance as at 31.12.2023 at fair values

2 619 989

14 725

2 634 714

Securities comprise the following:

Company

Number 31.12.2022

Change

Number 31.12.2023

Market price in original currency 31.12.2023

Valuation CHF mn 31.12.2023

Valuation CHF mn 31.12.2022

Ionis Pharmaceuticals

9 635 000

(1 045 000)

8 590 000

USD

50.59

365.6

336.4

Neurocrine Biosciences

2 730 000

(320 000)

2 410 000

USD

131.76

267.2

301.5

Argenx SE

892 503

(67 503)

825 000

USD

380.43

264.1

312.6

Vertex Pharmaceuticals

930 523

(290 523)

640 000

USD

406.89

219.1

248.4

Intra-Cellular Therapies

3 291 479

(251 479)

3 040 000

USD

71.62

183.2

161.0

Moderna

1 501 951

389 124

1 891 075

USD

99.45

158.2

249.4

Alnylam Pharmaceuticals

890 000

(30 300)

859 700

USD

191.41

138.5

195.5

Revolution Medicines

4 777 562

269 138

5 046 700

USD

28.68

121.8

105.2

Incyte

2 891 077

(741 077)

2 150 000

USD

62.79

113.6

214.7

Arvinas

2 136 412

358 119

2 494 531

USD

41.16

86.4

67.6

Celldex Therapeutics

1 800 000

616 296

2 416 296

USD

39.66

80.6

74.2

Macrogenics

8 929 963

1 000 000

9 929 963

USD

9.62

80.4

55.4

Agios Pharmaceuticals

4 030 792

(30 792)

4 000 000

USD

22.27

75.0

104.6

Sage Therapeutics

2 950 278

554 722

3 505 000

USD

21.67

63.9

104.0

Immunocore

965 654

965 654

USD

68.32

55.5

Relay Therapeutics

4 120 720

1 804 280

5 925 000

USD

11.01

54.9

56.9

Crispr Therapeutics

888 605

(8 605)

880 000

USD

62.60

46.4

33.4

Essa Pharma

7 879 583

7 879 583

USD

6.60

43.8

18.4

Exelixis

2 654 500

(654 500)

2 000 000

USD

23.99

40.4

39.4

Biohaven

1 075 000

1 075 000

USD

42.80

38.7

Scholar Rock Holding

2 132 725

2 132 725

USD

18.80

33.7

17.8

Black Diamond Therapeutics

5 377 839

3 140 000

8 517 839

USD

2.81

20.1

8.9

Wave Life Sciences

4 494 458

4 494 458

USD

5.05

19.1

29.1

Beam Therapeutics

693 121

693 121

USD

27.22

15.9

25.1

Fate Therapeutics

4 839 779

4 839 779

USD

3.74

15.2

45.1

Esperion Therapeutics

4 194 064

4 194 064

USD

2.99

10.6

24.2

Generation Bio Co.

3 608 280

3 608 280

USD

1.65

5.0

13.1

Molecular Templates 1)

11 192 003

283 686

1 029 820

USD

3.73

3.2

3.4

Myovant Sciences

5 872 639

(5 872 639)

USD

n.a.

146.4

Mersana Therapeutics

4 066 200

(4 066 200)

USD

n.a.

22.0

Kezar Life Sciences

3 000 000

(3 000 000)

USD

n.a.

19.5

Homology Medicines

1 622 522

(1 622 522)

USD

n.a.

1.9

Listed shares

2 620.0

3 035.2

Rivus Pharmaceuticals

USD

14.7

16.2

Unlisted shares

14.7

16.2

Total shares

2 634.7

3 051.3

Radius Health – Contingent Value Right

8 733 538

8 733 538

USD

0.00

Total derivative instruments

Total securities

2 634.7

3 051.3

1Share split 1:15 as at August 14, 2023

Securities are deposited with Bank Julius Baer & Co. Ltd., Zurich.

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